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Article

Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome.

Journal of translational medicine - 21 Nov 2012

Calemma Rosa, Ottaiano Alessandro, Trotta Anna Maria, Nasti Guglielmo, Romano Carmela, Napolitano Maria, Galati Domenico, Borrelli Pasquale, Zanotta Serena, Cassata Antonino, Castello Giuseppe, Iaffaioli Vincenzo Rosario, Scala Stefania

Abstract excerpt

BACKGROUND: Anti-EGFR monoclonal antibodies have shown efficacy in the treatment of metastatic colorectal cancer (mCRC). One of the mechanism is the antibody-dependent cell-mediated cytotoxicity (ADCC) in which Fc region of the antibody binds to the Fc gamma receptors (FcγR) expressed by immune cells. The present study investigated the association between single nucleotide polymorphisms of FcγRIIa and FcγRIIIa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23171437
DOI: 10.1186/1479-5876-10-232
PMCID: PMC3551834

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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