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Article

Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2013

Srivastava Raghvendra M, Lee Steve C, Andrade Filho Pedro A, Lord Christopher A, Jie Hyun-Bae, Davidson H Carter, López-Albaitero Andrés, Gibson Sandra P, Gooding William E, Ferrone Soldano, Ferris Robert L

Abstract excerpt

PURPOSE: Tumor antigen-specific monoclonal antibodies (mAb) block oncogenic signaling and induce Fcγ receptor (FcγR)-mediated cytotoxicity. However, the role of CD8(+) CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging. EXPERIMENTAL DESIGN: FcγRIIIa codon 158 polymorphism was correlated with survival in 107 cetuximab-treated patients with...

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Share to Antibodies, Monoclonal, Humanized
Share to Antibody-Dependent Cell Cytotoxicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 2

Share to Cetuximab

Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Receptor Cross-Talk

Share to Receptors, IgG

Share to Th1 Cells

Source

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Identifiers

PMID: 23444227
DOI: 10.1158/1078-0432.CCR-12-2426
PMCID: PMC3640274

Genes

EGFR
EGF
MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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