Article
Anionic lipid binding to the foreign protein MGS provides a tight coupling between phospholipid synthesis and protein overexpression in Escherichia coli.
Biochemistry - 20 Aug 2013
Ariöz Candan, Ye Weihua, Bakali Amin, Ge Changrong, Liebau Jobst, Götzke Hansjörg, Barth Andreas, Wieslander Ake, Mäler Lena
Abstract excerpt
Certain membrane proteins involved in lipid synthesis can induce formation of new intracellular membranes in Escherichia coli, i.e., intracellular vesicles. Among those, the foreign monotopic glycosyltransferase MGS from Acholeplasma laidlawii triggers such massive lipid synthesis when overexpressed. To examine the mechanism behind the increased lipid synthesis, we investigated the lipid binding properties of MGS...
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