Article
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.
Molecular biology of the cell - 1 Apr 2009
Guan Xue Li, Souza Cleiton M, Pichler Harald, Dewhurst Gisèle, Schaad Olivier, Kajiwara Kentaro, Wakabayashi Hirotomo, Ivanova Tanya, Castillon Guillaume A, Piccolis Manuele, Abe Fumiyoshi, Loewith Robbie, Funato Kouichi, Wenk Markus R, Riezman Howard
Abstract excerpt
Sterols and sphingolipids are limited to eukaryotic cells, and their interaction has been proposed to favor formation of lipid microdomains. Although there is abundant biophysical evidence demonstrating their interaction in simple systems, convincing evidence is lacking to show that they function together in cells. Using lipid analysis by mass spectrometry and a genetic approach on mutants in sterol metabolism,...
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