Article
Enhanced membrane protein expression by engineering increased intracellular membrane production.
Microbial cell factories - 9 Dec 2013
Guerfal Mouna, Claes Katrien, Knittelfelder Oskar, De Rycke Riet, Kohlwein Sepp D, Callewaert Nico
Abstract excerpt
BACKGROUND: Membrane protein research is frequently hampered by the low natural abundance of these proteins in cells and typically relies on recombinant gene expression. Different expression systems, like mammalian cells, insect cells, bacteria and yeast are being used, but very few research efforts have been directed towards specific host cell customization for enhanced expression of membrane proteins. Here we...
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