Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance.

Veterinary research - 16 Jul 2013

Kondadi Pradeep Kumar, Pacini Claudia, Revez Joana, Hänninen Marja-Liisa, Rossi Mirko

Abstract excerpt

Genomic analysis of a metronidazole resistant H. bizzozeronii strain revealed a frame length extension of the oxygen-insensitive NAD(P)H-nitroreductase HBZC1_00960 (RdxA), associated with the disruption of the C-terminal cysteine-containing conserved region (IACLXALGK). This was the result of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Helicobacter

Share to Metronidazole

Share to Nitroreductases

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 23865636
DOI: 10.1186/1297-9716-44-56
PMCID: PMC3734016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23865636-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance.PMID 23865636Read ↗

Comparative Genomics of Helicobacter pylori and the human-derived Helicobacter bizzozeronii CIII-1 strain reveal the molecular basis of the zoonotic nature of non-pylori gastric Helicobacter infections in humansSemantic proximity Read ↗

Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase.Semantic proximity Read ↗

Genetic analysis of Helicobacter pylori clinical isolates suggests resistance to metronidazole can occur without the loss of functional rdxA.Semantic proximity Read ↗

Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistance.Semantic proximity Read ↗

Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance.Semantic proximity Read ↗

Analysis of allelic variants of rdxA associated with metronidazole resistance in Helicobacter pylori: detection of common genotypes in rdxA by multiplex allele-specific polymerase chain reaction.Semantic proximity Read ↗

Mechanism of Metronidazole Resistance in Helicobacter pylori : Comparison of the rdxA Gene Sequences in 30 StrainsSemantic proximity Read ↗

Sequential Inactivation of <i>rdxA</i> (HP0954) and <i>frxA</i> (HP0642) Nitroreductase Genes Causes Moderate and High-Level Metronidazole Resistance in <i>Helicobacter pylori</i>Semantic proximity Read ↗

Characterization of Multiple <i>Helicobacter bizzozeronii</i> Isolates From a Finnish Patient With Severe Dyspeptic Symptoms and Chronic Active GastritisSemantic proximity Read ↗

DNA sequence analysis of rdxA and frxA from paired metronidazole-sensitive and -resistant Helicobacter pylori isolates obtained from patients with heteroresistance.Semantic proximity Read ↗

Insertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637.Semantic proximity Read ↗

Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.