Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.

doi:10.1158/1078-0432.CCR-13-0551

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Article

Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2013

Rutledge W Caleb, Kong Jun, Gao Jingjing, Gutman David A, Cooper Lee A D, Appin Christina, Park Yuna, Scarpace Lisa, Mikkelsen Tom, Cohen Mark L, Aldape Kenneth D, McLendon Roger E, Lehman Norman L, Miller C Ryan, Schniederjan Matthew J, Brennan Cameron W, Saltz Joel H, Moreno Carlos S, Brat Daniel J

Abstract excerpt

PURPOSE: Tumor-infiltrating lymphocytes (TIL) have prognostic significance in many cancers, yet their roles in glioblastoma have not been fully defined. We hypothesized that TILs in glioblastoma are associated with molecular alterations, histologies, and survival. EXPERIMENTAL DESIGN: We used data from The Cancer Genome Atlas (TCGA) to investigate molecular, histologic, and clinical correlates of TILs in...

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Identifiers

PMID: 23864165
DOI: 10.1158/1078-0432.CCR-13-0551
PMCID: PMC3865611

Genes

EGFR
PTEN
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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