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Article

The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.

The American journal of pathology - 1 May 2012

Cooper Lee A D, Gutman David A, Chisolm Candace, Appin Christina, Kong Jun, Rong Yuan, Kurc Tahsin, Van Meir Erwin G, Saltz Joel H, Moreno Carlos S, Brat Daniel J

Abstract excerpt

The Cancer Genome Atlas (TCGA) project has generated gene expression data that divides glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and mesenchymal. Because transcriptional class is only partially explained by underlying genomic alterations, we hypothesize that the tumor microenvironment may also have an impact. In this study, we focused on necrosis and angiogenesis because...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22440258
DOI: 10.1016/j.ajpath.2012.01.040
PMCID: PMC3354586

Genes

EBP
STAT3
FOSL2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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