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Article

Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

PloS one - 1 Jan 2013

Zhang Lili, Ma Ning, Liu Qingbin, Ma Yan

Abstract excerpt

We have been studying the action mechanisms of valproic acid (VPA) in fission yeast Schizosaccharomyces pombe by developing a genetic screen for mutants that show hypersensitivity to VPA. In the present study, we performed a genome-wide screen of 3004 haploid deletion strains and confirmed 148 deletion strains to be VPA sensitive. Of the 148 strains, 93 strains also showed sensitivity to another aliphatic acids...

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Identifiers

PMID: 23861937
DOI: 10.1371/journal.pone.0068738
PMCID: PMC3702616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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