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Article

Valproic acid affects membrane trafficking and cell-wall integrity in fission yeast.

Genetics - 1 Apr 2007

Miyatake Makoto, Kuno Takayoshi, Kita Ayako, Katsura Kosaku, Takegawa Kaoru, Uno Satoshi, Nabata Toshiya, Sugiura Reiko

Abstract excerpt

Valproic acid (VPA) is widely used to treat epilepsy and manic-depressive illness. Although VPA has been reported to exert a variety of biochemical effects, the exact mechanisms underlying its therapeutic effects remain elusive. To gain further insights into the molecular mechanisms of VPA action, a genetic screen for fission yeast mutants that show hypersensitivity to VPA was performed. One of the genes that we...

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Identifiers

PMID: 17287531
DOI: 10.1534/genetics.107.070946
PMCID: PMC1855103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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