Article
Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.
Cancer - 1 Oct 2013
Lipshultz Steven E, Lipsitz Stuart R, Kutok Jeffery L, Miller Tracie L, Colan Steven D, Neuberg Donna S, Stevenson Kristen E, Fleming Mark D, Sallan Stephen E, Franco Vivian I, Henkel Jacqueline M, Asselin Barbara L, Athale Uma H, Clavell Luis A, Michon Bruno, Laverdiere Caroline, Larsen Eric, Kelly Kara M, Silverman Lewis B
Abstract excerpt
BACKGROUND: Doxorubicin is associated with progressive cardiac dysfunction, possibly through the formation of doxorubicin-iron complexes leading to free-radical injury. The authors determined the frequency of hemochromatosis (HFE) gene mutations associated with hereditary hemochromatosis and their relationship with doxorubicin-associated cardiotoxicity in survivors of childhood high-risk acute lymphoblastic...
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