Article
Association of GSTM1 null variant with anthracycline-related cardiomyopathy after childhood cancer-A Children's Oncology Group ALTE03N1 report.
Cancer - 1 Sept 2020
Singh Purnima, Wang Xuexia, Hageman Lindsey, Chen Yanjun, Magdy Tarek, Landier Wendy, Ginsberg Jill P, Neglia Joseph P, Sklar Charles A, Castellino Sharon M, Dreyer Zoann E, Hudson Melissa M, Robison Leslie L, Blanco Javier G, Relling Mary V, Burridge Paul, Bhatia Smita
Abstract excerpt
BACKGROUND: Anthracycline-related cardiomyopathy is a leading cause of late morbidity in childhood cancer survivors. Glutathione S-transferases (GSTs) are a class of phase II detoxification enzymes that facilitate the elimination of anthracyclines. As free-radical scavengers, GSTs could play a role in oxidative damage-induced cardiomyopathy. Associations between the GSTμ1 (GSTM1) null genotype and...
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