Finding simple rules for discriminating folding rate change upon single mutation by statistical and learning methods.

Abstract excerpt

Protein folding rate is a valuable clue for understanding the variations in protein folding kinetics. The ability to accurately discriminate protein folding rate change is very helpful in protein design. However, there are fewer studies on the influence of amino acid substitution to protein folding rates. In our earlier studies, we constructed a dataset of 467 mutants upon amino acid substitution and proposed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Artificial Intelligence
• Share to Databases, Protein