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Article

Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy.

BMC bioinformatics - 19 Sept 2006

Jiang Rui, Yang Hua, Sun Fengzhu, Chen Ting

Abstract excerpt

BACKGROUND: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have been developed for predicting potential effects of amino acid substitutions using sequence, three-dimensional structural, and evolutionary properties of proteins, the applications are limited by the complication of the features and the...

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PMID: 16984653
DOI: 10.1186/1471-2105-7-417
PMCID: PMC1618409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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