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Article

PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders.

Genes and immunity - 1 Aug 2005

James E S, Harney S, Wordsworth B P, Cookson W O C M, Davis S J, Moffatt M F

Abstract excerpt

Variation in genes encoding costimulatory molecules expressed on lymphocytes has been expected to contribute to the genetic component of inflammatory disease, but only the gene encoding the inhibitory protein, CTLA-4, seems consistently to confer disease susceptibility. Studies in murine models implicate the inhibitory product of the pd1 gene, programmed death-1, in the maintenance of peripheral tolerance to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15959535
DOI: 10.1038/sj.gene.6364223

Genes

PDCD1

Provenance

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