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Article

The SWIB domain-containing DNA topoisomerase I of Chlamydia trachomatis mediates DNA relaxation.

Journal of bacteriology - 18 Sept 2025

Shen Li, Swoboda Abigail R, Diggs Caitlynn, Ferdous Shomita, Terrebonne Andrew, Santos Amanda, Wolf Noel, Lorenzo Carvajal Luis, Zhong Guangming, Ouellette Scot P, Tse-Dinh Yuk-Ching

Abstract excerpt

Chlamydia trachomatis has a DNA topoisomerase I with a unique C-terminal domain (CTD) homologous to eukaryotic SWIB domains. This study focused on determining the function of the SWIB domain-containing TopA from C. trachomatis (CtTopA). We demonstrated that, despite the lack of sequence similarity at the CTDs between CtTopA and TopA from Escherichia coli (EcTopA), full-length CtTopA removed negative DNA...

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Identifiers

PMID: 40793755
DOI: 10.1128/jb.00190-25
PMCID: PMC12445093

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