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Article

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.

mBio - 30 Dec 2014

Engström Patrik, Krishnan K Syam, Ngyuen Bidong D, Chorell Erik, Normark Johan, Silver Jim, Bastidas Robert J, Welch Matthew D, Hultgren Scott J, Wolf-Watz Hans, Valdivia Raphael H, Almqvist Fredrik, Bergström Sven

Abstract excerpt

UNLABELLED: In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed to be associated with the C. trachomatis surface, suggesting that its...

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Identifiers

PMID: 25550323
DOI: 10.1128/mBio.02304-14
PMCID: PMC4281921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25550323-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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