Article
Genetic modifier screens to identify components of a redox-regulated cell adhesion and migration pathway.
Methods in enzymology - 1 Jan 2013
Hurd Thomas Ryan, Leblanc Michelle Gail, Jones Leonard Nathaniel, DeGennaro Matthew, Lehmann Ruth
Abstract excerpt
Under normal physiological conditions, cells use oxidants, particularly H2O2, for signal transduction during processes such as proliferation and migration. Though recent progress has been made in determining the precise role H2O2 plays in these processes, many gaps still remain. To further understand this, we describe the use of a dominant enhancer screen to identify novel components of a redox-regulated cell...
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