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Article

Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch.

PLoS genetics - 1 Oct 2008

Zhou Dan, Xue Jin, Lai James C K, Schork Nicholas J, White Kevin P, Haddad Gabriel G

Abstract excerpt

Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current study, we used Drosophila melanogaster as a model to dissect the mechanisms underlying hypoxia-tolerance. A D. melanogaster strain that lives perpetually in an extremely low-oxygen environment (4% O2, an oxygen level that is...

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Identifiers

PMID: 18927626
DOI: 10.1371/journal.pgen.1000221
PMCID: PMC2556400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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