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Article

SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics.

Nature cell biology - 1 Dec 2013

Hung Ruei-Jiun, Spaeth Christopher S, Yesilyurt Hunkar Gizem, Terman Jonathan R

Abstract excerpt

Actin's polymerization properties are markedly altered by oxidation of its conserved Met 44 residue. Mediating this effect is a specific oxidation-reduction (redox) enzyme, Mical, that works with Semaphorin repulsive guidance cues and selectively oxidizes Met 44. We now find that this actin-regulatory process is reversible. Employing a genetic approach, we identified a specific methionine sulfoxide reductase...

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Identifiers

PMID: 24212093
DOI: 10.1038/ncb2871
PMCID: PMC4254815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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