Article
A stable CC-chemokine receptor (CCR)-5 tropic virus is correlated with the persistence of HIV RNA at less than 2.5 copies in successfully treated naïve subjects.
BMC infectious diseases - 11 Jul 2013
Parisi Saverio Giuseppe, Andreis Samantha, Mengoli Carlo, Scaggiante Renzo, Cruciani Mario, Ferretto Roberto, Manfrin Vinicio, Panese Sandro, Basso Monica, Boldrin Caterina, Bressan Stefania, Sarmati Loredana, Andreoni Massimo, Palù Giorgio
Abstract excerpt
BACKGROUND: To determine if tropism for CXCR4 or CCR5 correlates with cellular HIV DNA load, residual viraemia and CD4 count in 219 successfully treated naive subjects with HIV infection enrolled in five infectious diseases units in Northeastern Italy. METHODS: A subset of subjects, achieving plasma HIV RNA level <50 copies/ml after initiation of first-line therapy and maintaining it until follow-up time points,...
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