HIV-1 non-R5 tropism correlates with a larger size of the cellular viral reservoir and a detectable residual viremia in patients under suppressive ART.

doi:10.1016/j.jcv.2018.03.013

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Article

HIV-1 non-R5 tropism correlates with a larger size of the cellular viral reservoir and a detectable residual viremia in patients under suppressive ART.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2018

Lombardi Francesca, Belmonti Simone, Rapone Lucrezia, Borghetti Alberto, Ciccullo Arturo, Gagliardini Roberta, Baldin Gianmaria, Montagnani Francesca, Moschese Davide, Emiliozzi Arianna, Rossetti Barbara, De Luca Andrea, Di Giambenedetto Simona

Abstract excerpt

BACKGROUND: The influence of HIV-1 co-receptor usage on the course of therapy in subjects fully responding to ART has been poorly investigated. OBJECTIVES: To explore the relationship between co-receptor tropism and cellular reservoir size, residual viremia and subsequent virological outcome in ART-treated patients with HIV-1 RNA stable <50 copies/mL. STUDY DESIGN: Viral co-receptor usage was predicted by viral...

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PMID: 29656086
DOI: 10.1016/j.jcv.2018.03.013

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