Article
Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions.
Proteins - 1 Nov 2013
Moretti Rocco, Fleishman Sarel J, Agius Rudi, Torchala Mieczyslaw, Bates Paul A, Kastritis Panagiotis L, Rodrigues João P G L M, Trellet Mikaël, Bonvin Alexandre M J J, Cui Meng, Rooman Marianne, Gillis Dimitri, Dehouck Yves, Moal Iain, Romero-Durana Miguel, Perez-Cano Laura, Pallara Chiara, Jimenez Brian, Fernandez-Recio Juan, Flores Samuel, Pacella Michael, Praneeth Kilambi Krishna, Gray Jeffrey J, Popov Petr, Grudinin Sergei, Esquivel-Rodríguez Juan, Kihara Daisuke, Zhao Nan, Korkin Dmitry, Zhu Xiaolei, Demerdash Omar N A, Mitchell Julie C, Kanamori Eiji, Tsuchiya Yuko, Nakamura Haruki, Lee Hasup, Park Hahnbeom, Seok Chaok, Sarmiento Jamica, Liang Shide, Teraguchi Shusuke, Standley Daron M, Shimoyama Hiromitsu, Terashi Genki, Takeda-Shitaka Mayuko, Iwadate Mitsuo, Umeyama Hideaki, Beglov Dmitri, Hall David R, Kozakov Dima, Vajda Sandor, Pierce Brian G, Hwang Howook, Vreven Thom, Weng Zhiping, Huang Yangyu, Li Haotian, Yang Xiufeng, Ji Xiaofeng, Liu Shiyong, Xiao Yi, Zacharias Martin, Qin Sanbo, Zhou Huan-Xiang, Huang Sheng-You, Zou Xiaoqin, Velankar Sameer, Janin Joël, Wodak Shoshana J, Baker David
Abstract excerpt
Community-wide blind prediction experiments such as CAPRI and CASP provide an objective measure of the current state of predictive methodology. Here we describe a community-wide assessment of methods to predict the effects of mutations on protein-protein interactions. Twenty-two groups predicted the effects of comprehensive saturation mutagenesis for two designed influenza hemagglutinin binders and the results...
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