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Topologically inferring risk-active pathways toward precise cancer classification by directed random walk

10 Jul 2013

Abstract excerpt

MOTIVATION: The accurate prediction of disease status is a central challenge in clinical cancer research. Microarray-based gene biomarkers have been identified to predict outcome and outperform traditional clinical parameters. However, the robustness of the individual gene biomarkers is questioned because of their little reproducibility between different cohorts of patients. Substantial progress in treatment...

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PMID: 23842813
DOI: 10.1093/bioinformatics/btt373

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