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CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research

13 Oct 2022

Abstract excerpt

BACKGROUND: Pathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways. Moreover, different pathways exert their functions through crosstalk. However, existing PEA methods do not sufficiently integrate essential pathway features, including pathway crosstalk, molecular interactions, and network topologies, resulting in many risk pathways...

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PMID: 36229842
DOI: 10.1186/s13073-022-01119-6

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