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Article

Identifying cellular cancer mechanisms through pathway-driven data integration.

Bioinformatics (Oxford, England) - 15 Sept 2022

Windels Sam F L, Malod-Dognin Noël, Pržulj Nataša

Abstract excerpt

MOTIVATION: Cancer is a genetic disease in which accumulated mutations of driver genes induce a functional reorganization of the cell by reprogramming cellular pathways. Current approaches identify cancer pathways as those most internally perturbed by gene expression changes. However, driver genes characteristically perform hub roles between pathways. Therefore, we hypothesize that cancer pathways should be...

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PMID: 35916710
DOI: 10.1093/bioinformatics/btac493
PMCID: PMC9477533

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