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Pathway-based personalized analysis of cancer

1 Apr 2013

Abstract excerpt

We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined, in a context-specific manner, for every particular dataset and type of cancer that is being investigated. The algorithm transforms gene-level information into pathway-level information, generating a compact and biologically relevant representation of each...

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PMID: 23547110
DOI: 10.1073/pnas.1219651110

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