Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trachea epithelium as a "canary" for cigarette smoking-induced biologic phenotype of the small airway epithelium.

Clinical and translational science - 1 Aug 2009

Turetz Meredith L, O'Connor Timothy P, Tilley Ann E, Strulovici-Barel Yael, Salit Jacqueline, Dang David, Teater Matthew, Mezey Jason, Clark Andrew G, Crystal Ronald G

Abstract excerpt

The initial site of smoking-induced lung disease is the small airway epithelium, which is difficult and time consuming to sample by fiberoptic bronchoscopy. We developed a rapid, office-based procedure to obtain trachea epithelium without conscious sedation from healthy nonsmokers (n= 26) and healthy smokers (n= 19, 27 +/- 15 pack-year). Gene expression differences (fold change >1.5, p < 0.01, Benjamini-Hochberg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelium
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nicotiana

Share to Oligonucleotide Array Sequence Analysis

Share to Principal Component Analysis

Share to Smoking

Share to Trachea

Share to Translational Research, Biomedical

Source

Open in PubMed Open full text

Identifiers

PMID: 20443905
DOI: 10.1111/j.1752-8062.2009.00129.x
PMCID: PMC3875387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trachea epithelium as a "canary" for cigarette smoking-induced biologic phenotype of the small airway epithelium.PMID 20443905Read ↗

Modification of gene expression of the small airway epithelium in response to cigarette smoking.Semantic proximity Read ↗

Effects of cigarette smoke on the human airway epithelial cell transcriptomeSemantic proximity Read ↗

Biologic phenotyping of the human small airway epithelial response to cigarette smoking.Semantic proximity Read ↗

Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epitheliumSemantic proximity Read ↗

Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokersSemantic proximity Read ↗

RNA-Seq quantification of the human small airway epithelium transcriptomeSemantic proximity Read ↗

Transcriptomic Studies of the Airway Field of Injury Associated with Smoking-Related Lung DiseaseSemantic proximity Read ↗

Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolutionSemantic proximity Read ↗

Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression.Semantic proximity Read ↗

Variability in small airway epithelial gene expression among normal smokers.Semantic proximity Read ↗

Cigarette Smoke Specifically Affects Small Airway Epithelial Cell Populations and Triggers the Expansion of Inflammatory and Squamous Differentiation Associated Basal CellsSemantic proximity Read ↗

Modification of gene expression of the small airway epithelium in response to cigarette smokingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.