Current Smoking Alters Gene Expression and DNA Methylation in the Nasal Epithelium of Patients with Asthma

Abstract excerpt

Abstract Current smoking contributes to worsened asthma prognosis and more severe symptoms and limits the beneficial effects of corticosteroids. As the nasal epithelium can reflect smoking-induced changes in the lower airways, it is a relevant source to investigate changes in gene expression and DNA methylation. This study explores gene expression and DNA methylation changes in current and ex-smokers with asthma....