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Article

Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival.

PloS one - 1 Jan 2013

Yao Yu, Chan Aden Ka-Yin, Qin Zhi Yong, Chen Ling Chao, Zhang Xin, Pang Jesse Chung-Sean, Li Hiu Ming, Wang Yin, Mao Ying, Ng Ho-Keung, Zhou Liang Fu

Abstract excerpt

Recurrence and progression to higher grade lesions are characteristic behaviors of gliomas. Though IDH1 mutation frequently occurs and is considered as an early event in gliomagenesis, little is known about its role in the recurrence and progression of gliomas. We therefore analysed IDH1 and IDH2 status at codon 132 of IDH1 and codon 172 of IDH2 by direct sequencing and anti-IDH1-R132H immunohistochemistry in 53...

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Identifiers

PMID: 23840696
DOI: 10.1371/journal.pone.0067421
PMCID: PMC3696098

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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