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Article

Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients.

PloS one - 3 Feb 2010

Donlin Maureen J, Cannon Nathan A, Aurora Rajeev, Li Jia, Wahed Abdus S, Di Bisceglie Adrian M, Tavis John E

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) has six major genotypes, and patients infected with genotype 1 respond less well to interferon-based therapy than other genotypes. African American patients respond to interferon alpha-based therapy at about half the rate of Caucasian Americans. The effect of HCV's genetic variation on treatment outcome in both racial groups is poorly understood. METHODOLOGY: We determined the...

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Identifiers

PMID: 20140258
DOI: 10.1371/journal.pone.0009032
PMCID: PMC2815788

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