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Article

Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans.

The Journal of clinical investigation - 1 Jan 2009

Aurora Rajeev, Donlin Maureen J, Cannon Nathan A, Tavis John E

Abstract excerpt

Hepatitis C virus (HCV) is a common RNA virus that causes hepatitis and liver cancer. Infection is treated with IFN-alpha and ribavirin, but this expensive and physically demanding therapy fails in half of patients. The genomic sequences of independent HCV isolates differ by approximately 10%, bu...

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Identifiers

PMID: 19104147
DOI: 10.1172/JCI37085
PMCID: PMC2613460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19104147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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