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Hypoxia-Inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors

20 Jun 2013

Abstract excerpt

CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood. In this study, we analyzed the activity of five putative promoters (P1-P5) of CD133 in human embryonic kidney (HEK) 293 cells and colon cancer cell line WiDr, and found that the...

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PMID: 23840432
DOI: 10.1371/journal.pone.0066255

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