CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).

doi:10.1016/j.canlet.2018.09.009

Article

CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).

Cancer letters - 1 Dec 2018

Kim Somi, Cho Chang Yun, Lee Doohyung, Song Dae-Geun, Kim Hye-Jin, Jung Jae Woo, Kim Ji Eon, Park Dasomi, Lee Haesong, Um Hyejin, Park Jinsoo, Choi Yoonjeong, Kim Yoomin, Nam Seo Hee, Lee Jung Weon

Abstract excerpt

CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD133, TM4SF5, CD44, and protein tyrosine phosphatase receptor type F (PTPRF) in a three-dimensional...

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CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).

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