Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK/ERK signaling pathway

21 Oct 2016

Abstract excerpt

Abstract Human placenta-derived mesenchymal stem cells (hPMSCs) reside in a physiologically low-oxygen microenvironment. Hypoxia influences a variety of stem cell cellular activities, frequently involving hypoxia-inducible factor-2 alpha (HIF-2α). This research showed that hPMSCs cultured in hypoxic conditions (5% O 2 ) exhibited a more naïve morphology and had a higher proliferative capability and higher HIF-2α...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor Research
Share to Mesenchymal stem cell research
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27765951
DOI: 10.1038/srep35489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK/ERK signaling pathwayPMID 27765951Read ↗

Increased Proliferation and Analysis of Differential Gene Expression in Human Wharton's Jelly-derived Mesenchymal Stromal Cells under HypoxiaSemantic proximity Read ↗

Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxiaSemantic proximity Read ↗

Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc ExpressionSemantic proximity Read ↗

Hypoxia Promotes Osteogenesis of Human Placental-Derived Mesenchymal Stem Cells.Semantic proximity Read ↗

Hypoxic Culture Maintains Self-Renewal and Enhances Embryoid Body Formation of Human Embryonic Stem CellsSemantic proximity Read ↗

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.Semantic proximity Read ↗

Cell Metabolism Under Microenvironmental Low Oxygen Tension Levels in Stemness, Proliferation and PluripotencySemantic proximity Read ↗

Biology of hypoxia-inducible factor-2alpha in development and disease.Semantic proximity Read ↗

Hypoxic downregulation of cellular proliferation and loss of phenotype stability in human osteoblasts is mediated by HIF-1α.Semantic proximity Read ↗

Convergence of Hypoxia and TGFβ Pathways on Cell Cycle Regulation in Human Hematopoietic Stem/Progenitor CellsSemantic proximity Read ↗

Suppression of hypoxia-induced stemness and chemoresistance in ovarian tumorsSemantic proximity Read ↗

Transcriptomic responses to hypoxia in endometrial and decidual stromal cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.