Article
Nanog induces hyperplasia without initiating tumors.
Stem cell research - 1 Sept 2014
Fischedick Gerrit, Wu Guangming, Adachi Kenjiro, Araúzo-Bravo Marcos J, Greber Boris, Radstaak Martina, Köhler Gabriele, Tapia Natalia, Iacone Roberto, Anastassiadis Konstantinos, Schöler Hans R, Zaehres Holm
Abstract excerpt
Though expression of the homeobox transcription factor Nanog is generally restricted to pluripotent cells and early germ cells, many contradictory reports about Nanog's involvement in tumorigenesis exist. To address this, a modified Tet-On system was utilized to generate Nanog-inducible mice. Following prolonged Nanog expression, phenotypic alterations were found to be restricted to the intestinal tract, leaving...
Topics
- Animals
- CDX2 Transcription Factor
- Cell Proliferation
- Cell Transformation, Neoplastic
- Colon
- Colonic Neoplasms
- Epithelial Cells
- Gene Expression Regulation
- Gene Knockdown Techniques
- Genotype