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Article

NANOGP8: evolution of a human-specific retro-oncogene.

G3 (Bethesda, Md.) - 1 Nov 2012

Fairbanks Daniel J, Fairbanks Aaron D, Ogden T Heath, Parker Glendon J, Maughan Peter J

Abstract excerpt

NANOGP8 is a human (Homo sapiens) retrogene, expressed predominantly in cancer cells where its protein product is tumorigenic. It arose through retrotransposition from its parent gene, NANOG, which is expressed predominantly in embryonic stem cells. Based on identification of fixed and polymorphic variants in a genetically diverse set of human NANOG and NANOGP8 sequences, we estimated the evolutionary origin of...

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Source

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Identifiers

PMID: 23173096
DOI: 10.1534/g3.112.004366
PMCID: PMC3484675

Genes

NANOGP8
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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