Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations.

Biology open - 10 Sept 2020

Yu Zhen, Dmitrieva Natalia I, Walts Avram D, Jin Hui, Liu Yangtengyu, Ping Xianfeng, Ferrante Elisa A, Qiu Lugui, Holland Steven M, Freeman Alexandra F, Chen Guibin, Boehm Manfred

Abstract excerpt

Human induced pluripotent stem cell (iPSC) technology has opened exciting opportunities for stem-cell-based therapy. However, its wide adoption is precluded by several challenges including low reprogramming efficiency and potential for malignant transformation. Better understanding of the molecular mechanisms of the changes that cells undergo during reprograming is needed to improve iPSCs generation efficiency...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Immunoglobulin E

Share to Induced Pluripotent Stem Cells

Share to Job Syndrome

Share to Loss of Function Mutation

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 32580970
DOI: 10.1242/bio.052662
PMCID: PMC7502598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations.PMID 32580970Read ↗

Generation of human induced pluripotent stem cell lines (NIHTVBi011-A, NIHTVBi012-A, NIHTVBi013-A) from autosomal dominant Hyper IgE syndrome (AD-HIES) patients carrying STAT3 mutation.Semantic proximity Read ↗

Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing.Semantic proximity Read ↗

STAT3 mutation-associated airway epithelial defects in Job syndrome.Semantic proximity Read ↗

Allele-Specific Disruption of a Common STAT3 Autosomal Dominant Allele Is Not Sufficient to Restore Downstream Signaling in Patient-Derived T Cells.Semantic proximity Read ↗

Heterelogous expression of mutated HLA-G decreases immunogenicity of human embryonic stem cells and their epidermal derivatives.Semantic proximity Read ↗

Dysregulated Airway Host Defense in Hyper IgE Syndrome due to STAT3 MutationsSemantic proximity Read ↗

Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.Semantic proximity Read ↗

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.Semantic proximity Read ↗

Generation of three induced pluripotent stem cell lines (UQACi003-A, UQACi004-A, and UQACi006-A) from three patients with KRT5 epidermolysis bullosa simplex mutations.Semantic proximity Read ↗

Pluripotency factor Nanog is tumorigenic by deregulating DNA damage response in somatic cells.Semantic proximity Read ↗

Epithelial proliferation in inflammatory skin disease is regulated by tetratricopeptide repeat domain 7 (Ttc7) in fibroblasts and lymphocytes.Semantic proximity Read ↗

Engineered Human Skin Substitutes Undergo Large-Scale Genomic Reprogramming and Normal Skin-Like Maturation after Transplantation to Athymic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.