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Article

Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24.

The Journal of physiology - 15 Sept 2013

Hanft Laurin M, Biesiadecki Brandon J, McDonald Kerry S

Abstract excerpt

According to the Frank-Starling relationship, greater end-diastolic volume increases ventricular output. The Frank-Starling relationship is based, in part, on the length-tension relationship in cardiac myocytes. Recently, we identified a dichotomy in the steepness of length-tension relationships in mammalian cardiac myocytes that was dependent upon protein kinase A (PKA)-induced myofibrillar phosphorylation....

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Identifiers

PMID: 23836688
DOI: 10.1113/jphysiol.2013.258400
PMCID: PMC3784197

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