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Evolution of the regulatory control of vertebrate striated muscle: the roles of troponin I and myosin binding protein-C

19 May 2010

Abstract excerpt

Troponin I (TnI) and myosin binding protein-C (MyBP-C) are key regulatory proteins of contractile function in vertebrate muscle. TnI modulates the Ca(2+) activation signal, while MyBP-C regulates cross-bridge cycling kinetics. In vertebrates, each protein is distributed as tissue-specific paralogs in fast skeletal (fs), slow skeletal (ss), and cardiac (c) muscles. The purpose of this study is to characterize how...

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PMID: 20484158
DOI: 10.1152/physiolgenomics.00055.2010

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