Article

Genetic excision of the regulatory cardiac troponin I extension in high heart rate mammal clades

2023-05-22

Abstract excerpt

Mammalian cardiac troponin I (cTnI) contains a highly conserved N-terminal extension harboring protein kinase A targets (Ser 23/24 ) which are phosphorylated during ß-adrenergic stimulation to increase cardiomyocyte relaxation rate. Here, we show that the Ser 23/24 encoding exon 3 of TNNI3 was pseudoexonized multiple times in shrews and moles to mimic Ser 23/24 phosphorylation without adrenergic stimulation, f...

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Literature Corpus work: ca103e67-c93a-5976-860a-7ada6f765c0a
DOI: 10.1101/2023.05.19.541292

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