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Article

swIFN-β promotes genetic mutation of porcine reproductive and respiratory syndrome virus in Marc-145.

Veterinary microbiology - 27 Sept 2013

He Dongsheng, Niu Xiaoyun, Jiang Aixiang, Su Danping, Zhong Wang, Hu Jing, Wang Yanli, Chen Ruiai

Abstract excerpt

This result, for the first time, demonstrates that under swine interferon-β (swIFN-β) immune pressure molecular variation of porcine reproductive and respiratory syndrome virus (PRRSV) accelerates. PRRSV-A1 strain was continuously propagated in Marc-145 cells primed with swIFN-β for 20 passages to develop RRRSV-A1βf20 strains while PRRSV-A1f20 was control without swIFN-β respectively. NSP2, ORF3, ORF5 and ORF6...

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Identifiers

PMID: 23834966
DOI: 10.1016/j.vetmic.2013.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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