The Significance of the 98th Amino Acid in GP2a for Porcine Reproductive and Respiratory Syndrome Virus Adaptation in Marc-145 Cells.

doi:10.3390/v16050711

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The Significance of the 98th Amino Acid in GP2a for Porcine Reproductive and Respiratory Syndrome Virus Adaptation in Marc-145 Cells.

Viruses - 30 Apr 2024

Chen Yao, Huo Zhantang, Jiang Qi, Qiu Zhiheng, Shao Zheng, Ma Chunquan, Zhang Guihong, Li Qi

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the pig industry. Marc-145 cells are widely used for PRRSV isolation, vaccine production, and investigations into virus biological characteristics. Despite their significance in PRRSV research, Marc-145 cells struggle to isolate specific strains of the North American virus genotype (PRRSV-2). The involvement of...

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PMID: 38793594
DOI: 10.3390/v16050711
PMCID: PMC11125946

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