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Article

Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions.

Aging - 1 Jun 2013

Favret Sandra, Binet Francois, Lapalme Eric, Leboeuf Dominique, Carbadillo Jose, Rubic Tina, Picard Emilie, Mawambo Gaelle, Tetreault Nicolas, Joyal Jean-Sebastien, Chemtob Sylvain, Sennlaub Florian, Sangiovanni John Paul, Guimond Martin, Sapieha Przemyslaw

Abstract excerpt

Age-related macular degeneration (AMD) is a prominent cause of blindness in the Western world. To date, its molecular pathogenesis as well as the sequence of events leading to retinal degeneration remain largely ill-defined. While the invasion of choroidal neovessels in the retina is the primary mechanism that precipitates loss of sight, an earlier dry form precedes it. Here we provide the first evidence for the...

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Source

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Identifiers

PMID: 23833031
DOI: 10.18632/aging.100563
PMCID: PMC3832265

Genes

SUCNR1
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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