Article

P2Y6R-positive microglia sense the stress metabolite uridine and exacerbate photoreceptor degeneration in the retina

2025-05-12

Abstract excerpt

<title>Abstract</title> <p>Retinitis pigmentosa (RP) is an incurable blinding disorder characterized by progressive photoreceptor degeneration. While metabolic stress has been implicated in RP progression, the neuroimmune mechanisms driving this process remain poorly understood. In this study, we employed time-series untargeted metabolomics to profile temporal metabolic changes during RP pathogenesis using the re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 46062c46-7ff6-5c0c-a57a-9658f7666624
DOI: 10.21203/rs.3.rs-6578878/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

P2Y6R-positive microglia sense the stress metabolite uridine and exacerbate photoreceptor degeneration in the retinaDOI 10.21203/rs.3.rs-6578878/v1Read

Single-cell analysis of the human retina reveals stage-linked microglial states and neural-immune circuit rewiring in diabetic retinopathySemantic proximity Read

Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosaSemantic proximity Read

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegenerationSemantic proximity Read

Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathySemantic proximity Read

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.Semantic proximity Read

Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases.Semantic proximity Read

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.Semantic proximity Read

Retinal scRNAseq reveals cell-type-specific responses to bacterial infectionSemantic proximity Read

Retinitis Pigmentosa Is Associated With Shifts in The Gut MicrobiomeSemantic proximity Read

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 InteractionsSemantic proximity Read

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencingSemantic proximity Read

Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosaSemantic proximity Read