Article
How cells change their phenotype.
Nature reviews. Molecular cell biology - 1 Mar 2002
Tosh David, Slack Jonathan M W
Abstract excerpt
Recent attention has focused on the remarkable ability of adult stem cells to produce differentiated cells from embryologically unrelated tissues. This phenomenon is an example of metaplasia and shows that embryological commitments can be reversed or erased under certain circumstances. In some cases, even fully differentiated cells can change their phenotype (transdifferentiation). This review examines recently...
Topics
- Adult
- Animals
- Cell Differentiation
- Humans
- Metaplasia
- Models, Biological
- Phenotype
- Stem Cells