Article
Persistent changes of corticostriatal plasticity in dt(sz) mutant hamsters after age-dependent remission of dystonia.
Neuroscience - 10 Oct 2013
Avchalumov Y, Volkmann C E, Rückborn K, Hamann M, Kirschstein T, Richter A, Köhling R
Abstract excerpt
Abnormal plasticity in the cortico-basal ganglia-thalamocortical loop has been suggested to represent a key factor in the pathophysiology of dystonia. In a model of primary paroxysmal dystonia, the dt(sz) mutant hamster, previous experiments have shown a strongly increased long-term potentiation (LTP) in comparison to non-dystonic control hamsters. These basal changes, i.e. in the absence of dystonia, were found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.