Article
Overexpression of nicastrin increases Abeta production.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2003
Murphy M Paul, Das Pritam, Nyborg Andrew C, Rochette Marjorie J, Dodson Mark W, Loosbrock Nicole M, Souder Terrance M, McLendon Chris, Merit Sami L, Piper Siân C, Jansen Karen R, Golde Todd E
Abstract excerpt
Gamma-secretase cleavage is the final proteolytic step that releases the amyloid beta-peptide (Abeta) from the amyloid beta-protein precursor (APP). Significant evidence indicates that the presenilins (PS) are catalytic components of a high molecular weight gamma-secretase complex. The glycoprotein nicastrin was recently identified as a functional unit of this complex based on 1) binding to PS and 2) the ability...
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