Article

Dominant substitutions underlying the antigenic evolution of H5 influenza virus

2025-02-26

Abstract excerpt

<title>Abstract</title> <p>Highly pathogenic avian influenza (HPAI) H5 viruses have recently been documented in mammals including humans, posing a major threat to global public health. To prevent a potential H5 pandemic, it is critical to elucidate the antigenic evolutionary pattern and identify key drivers underlying its evolution. In this study, we constructed a comprehensive antigenic map of H5 influenza virus...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5329e4c-ee09-5044-a139-a5dec54fd7b2
DOI: 10.21203/rs.3.rs-6040842/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dominant substitutions underlying the antigenic evolution of H5 influenza virusDOI 10.21203/rs.3.rs-6040842/v1Read

Key Amino Acid Residues That Determine the Antigenic Properties of Highly Pathogenic H5 Influenza Viruses Bearing the Clade 2.3.4.4 Hemagglutinin GeneSemantic proximity Read

Highly pathogenic avian influenza H5N1: history, current situation, and outlookSemantic proximity Read

Comprehensive Evolutionary and Structural Analysis of the H5N1 Clade 2.4.3.4b Influenza a Virus Based on the Sequences and Data Mining of the Hemagglutinin, Nucleoprotein, and Neuraminidase Genes Across Multiple HostsSemantic proximity Read

Amino acid substitutions in antigenic region B of hemagglutinin play a critical role in the antigenic drift of subclade 2.3.4.4 highly pathogenic H5NX influenza virusesSemantic proximity Read

A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genesSemantic proximity Read

Mutational antigenic landscape of prevailing H9N2 influenza virus hemagglutinin spectrum.Semantic proximity Read

Avian influenza virus neuraminidase stalk length and haemagglutinin glycosylation patterns reveal molecularly directed reassortment promoting the emergence of highly pathogenic clade 2.3.4.4b A (H5N1) virusesSemantic proximity Read

Evolution and mutational landscape of highly pathogenic avian influenza strain A(H5N1) in the current outbreak in the USA and global landscape.Semantic proximity Read

Unravelling Influenza A (H3N2): From Viral Evolution to Global ImpactSemantic proximity Read

Global distribution, receptor binding, and cross-species transmission of H6 influenza viruses: risks and implications for humansSemantic proximity Read

Mapping Haemagglutinin Residues Driving Antigenic Diversity in H5Nx Avian Influenza VirusesSemantic proximity Read

The episodic resurgence of highly pathogenic avian influenza H5 virusSemantic proximity Read