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Article

Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology.

Brain : a journal of neurology - 1 Aug 2013

Perez-Nievas Beatriz G, Stein Thor D, Tai Hwan-Ching, Dols-Icardo Oriol, Scotton Thomas C, Barroeta-Espar Isabel, Fernandez-Carballo Leticia, de Munain Estibaliz Lopez, Perez Jesus, Marquie Marta, Serrano-Pozo Alberto, Frosch Mathew P, Lowe Val, Parisi Joseph E, Petersen Ronald C, Ikonomovic Milos D, López Oscar L, Klunk William, Hyman Bradley T, Gómez-Isla Teresa

Abstract excerpt

Clinico-pathological correlation studies and positron emission tomography amyloid imaging studies have shown that some individuals can tolerate substantial amounts of Alzheimer's pathology in their brains without experiencing dementia. Few details are known about the neuropathological phenotype of these unique cases that might prove relevant to understanding human resilience to Alzheimer's pathology. We conducted...

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Identifiers

PMID: 23824488
DOI: 10.1093/brain/awt171
PMCID: PMC3722351

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